Chromium & Copper
The information presented is based on Cellular trace mineral analysis - not Serum / Blood measurements.
RDA / DRI, synergists, antagonists, side effects, & additional deficiency / overdose symptoms are listed below.
Chromium (Cr) and Copper (Cu) are associated trace elements, and considered essential to human health.
Next to calcium and magnesium, chromium and copper are important nutrients for their anti-inflammatory
properties. While neither one - with few exceptions - is generally found to be very deficient level-wise,
chromium is on average always lower than copper, with virtually no exceptions. Copper on the other hand is
elevated in the majority of patients, which creates a chronic copper / chromium conflict ratio-wise in these
Of thousands of patients tested since the mid 1970s from different
continents around the world, nearly 90% exhibited a chemical profile
that in addition to their own unique chemistry, contained an under-
lying pattern that reflected the impact of elevated copper levels
on various opposing nutrients, which include Vitamin C, chromium,
sulfur, nickel, molybdenum, and hesperidin, an essential flavonoid,
There are other copper antagonists such as zinc, however while zinc
is generally documented as such in the nutritional literature, it is not
only the weakest of all copper antagonists, but its action on copper
takes place only on an intestinal level, so once copper goes into
storage, zinc will have no effect on lowering copper any longer. The
only time zinc could become a threat to copper is in situations where
either copper levels are already on the low side and high amounts of
zinc are ingested, or when potassium and calcium - being "synergistic allies" to copper - are well below normal.
Many people exhibit high levels of zinc and copper, in which case a common denominator such as Vitamin C
has to be supplemented in larger amounts to help lower both, while foods such as shellfish, nuts, wheat germ
(containing high levels of copper and zinc), should be avoided. One major reason why some people require
a much higher intake of Vitamin C compared to others is that they exhibit very high levels of copper, which in
Although chromium appears to be normal on the following graph, it is very low in ratio to copper, its associ-
ated element, so when supplementing chromium, its level will generally not go up at first, but it will gradually
lower copper instead, and in the example below, potassium, since they are high in ratio to chromium. Only
after copper and potassium have been reduced to normal levels, chromium may at that point start to go up.
However, sufficient amounts of chromium are rarely used, so in practice, copper and potassium will just come
down closer to normal, while chromium levels stay the same.
Magnesium almost always goes up following long-term chromium supplementation because of its synergism
with chromium, and as a result of potassium (which is a magnesium antagonist) going down, and thus not
exerting an inhibiting effect on magnesium any longer.
Copper is present in all tissues. The average adult body contains about 80 to 120mg of copper, of which
most of it is stored in the liver. It is an important catalyst in the formation of the oxygen-carrying molecule
hemoglobin. Copper is transferred by albumin across the gut wall and carried to the liver where it is formed
into ceruloplasmin, a copper transport protein. Sufficient ceruloplasmin levels affect a decrease in the
absorption of copper to minimize copper toxicity.
Copper is an essential component of several physiologically important enzymes, including:
• cytochrome oxidase, which is necessary for energy metabolism, cellular respiration, and myelin formation,
• superoxide dismutase (SOD), which helps slow down age-related deterioration of the body, protects from
developing chemical sensitivities (along with polyphenol oxidase), and it is important for normal humoral
• histaminase, which breaks down histamine, to control allergies and inflammation,
• lysil oxidase, which is necessary for the formation of the cross-links of collagen and elastin,
• tyrosinase, which is associated with normal pigmentation and keratinization of hair,
• dopamine-beta-hydroxylase, with which copper serves as a co-factor in the synthesis of norepinephrine,
an important neurotransmitter and adrenal hormone that affects fatigue, mood and depression.
Chronically elevated copper levels in most patients may result from one-sided diets that lack co-factors or
copper antagonists, or from the fact that many copper-rich foods are somewhat addictive, such as cocoa,
chocolate products, colas, coffee, or tea. Other copper sources include seafood / shellfish, seeds and nuts,
soy products, liver, foods or beverages that are cooked or stored in copper containers (beer), tap water
(copper plumbing), and copper IUDs.
Chromium occurs in any oxidation state from -2 to +6. Trivalent chromium (Cr+3) is the biologically active
form, while hexavalent chromium (Cr+6) is potentially toxic to humans. GTF (Glucose Tolerance Factor)
chromium is essential in helping regulate carbohydrate metabolism by improving the uptake of glucose into
the cells so it can be metabolized to produce energy (ATP). It consists of chromium in the trivalent state -
nicotinic acid, and the three amino acids glycine, glutamic acid and cysteine.
Chromium is able to improve cholesterol and triglyceride status, however while small amounts are necessary
for normal carbohydrate metabolism and to help with blood sugar management in diabetics, supplementing
higher amounts of chromium will not reverse Type II diabetes, as some sources claim.
On a similar note, Chromium Picolinate (chromium + picolinic acid) does not increase lean muscle tissue
and decrease body fat, as advertised by other sources. In fact, in contrast to the control groups, some of
the participants in the chromium picolinate group actually gained weight (one of my patients took part in
that research), and one published medical report stresses the implications of analogues of picolinic acid being
able to cause significant behavioral changes in those with an increased susceptibility for mood disorders.
Chromium picolinate is clearly the least desirable form to be used for supplementation (see below for more
Tissue concentrations of chromium vary considerably in people from different parts of the world, with amounts
in people living in Asia for example being up to five times higher compared to those in people living in the US.
These higher chromium levels may be one reason for a lower incidence of bone loss, or sugar metabolism
disorders in these regions or countries. In addition, excessive sugar intake - prevalent in Western societies -
increases chromium loss and accelerates already declining Cr levels due to increasing age, which worsens
medical conditions associated with lowered chromium levels.
There are also lower soil levels of chromium in North America, and the refining process of food (sugar cane,
whole grains) reduces sources of chromium as well. Exercise and trauma also contribute to chromium loss,
and it is interesting to note that in laboratory animals, extra chromium supplementation resulted in a life span
increase of up to 33%.
Uptake of various forms of chromium, including GTF chromium is in a low 1 - 3% range, with the absorption of
Chelated Chromium being usually closer to 25%, so chelated chromium is the preferable choice for specific
medical applications. For instance, when chromium is used for inflammatory conditions such as an acute
bladder infection (cystitis), taking 20,000 mcg of GTF chromium has little or no effect at all on improving the
symptoms, while 2,000 - 3,000 mcg / day of chelated chromium will rectify most cases of cystitis, or it can
be used to resolve chronic bladder infections by having patients take a lower, preventive maintenance
amount in the 500 mcg - 1,000 mcg range per day.
Osteoporosis of trabecular bone (spine, or end-part of bone) is frequently caused by chromium being very
low in ratio to either copper, potassium, selenium, and/or rarely, vanadium. Chromium is required for proper
parathyroid functions, so any of these Cr antagonists can become responsible for bone loss if supplemented
needlessly, or if their levels remain too high too long for any other dietary or genetic reason. However, one
other major factor that is responsible for bone loss as a result of its chromium-lowering effect - particularly
in Western Societies - and which is being totally overlooked is Sugar, and all other Simple Carbohydrate
Cellular / Intracellular Attributes and Interactions:
Magnesium, zinc, manganese, Vitamin B15.
Chromium Antagonists / Inhibitors:
Selenium, vanadium, potassium, cobalt, copper,
iodine, Vitamin B12, rutin, sugar, alcohol, fat.
Calcium, potassium, iron, Vitamin E.
Copper Antagonists / Inhibitors:
Sulfur, molybdenum, zinc, nickel, chromium, tin,
Vitamin B6, Vitamin C, hesperidin, insoluble fiber.
Low Levels / Deficiency - Symptoms and/or Risk Factors:
Reduced glucose tolerance / impaired glucose
metabolism, weakened immune system, increased
susceptibility for infections (e.g. bladder, left tonsil),
trabecular bone loss, inflammatory joint disease,
elevated total cholesterol, birth defects, reduced
life expectancy, nerve degeneration.
Anemia, increased susceptibility for infections,
weakened immune system, hormonal disorders,
increased risk for (colon) cancer, miscarriage,
trabecular bone loss, inflammatory joint disease,
premature graying of hair / loss of hair color,
vascular degeneration, insomnia, stroke, irregular
heart beat (arrhythmia), weight loss, leukopenia,
nerve degeneration, cardiomyopathy (in rats).
Spinal / joint degeneration, depressed immune
system, lymphatic swelling,
Please Note: Additional (rare) overdose / toxicity
symptoms are the result of a high chromium intake
causing deficiencies of other elements or nutrients.
These are found in their respective "Deficiency"
category and include potassium, copper, vanadium,
selenium, cobalt, iodine, Vitamin B12, and rutin.
High levels / Overdose / Toxicity / Negative Side Effects - Symptoms and/or Risk Factors:
Wilson's disease, anemia, nausea, vomiting,
abdominal pain, moodiness, violent behavior,
ADD / ADHD, depression, confusion, weight gain,
arthritis, joint / spinal degeneration, higher risk for
some cancers, vascular degeneration (aneurysm,
bruising, hemorrhoids, varicose veins), increased
susceptibility for infections, heart disease & stroke.
Brewer's yeast, beef, liver, chicken, dairy products,
eggs, potatoes, whole-grain products, fish / seafood,
green peppers, bananas, beer, drinking water.
Wheat germ, oats, fish / shellfish, mushrooms, tea,
soybeans, seeds, coffee, cocoa products, liver, nuts,
drinking water (copper plumbing), copper IUDs. ¤
Chromium Picolinate only:
Weight gain, behavioral disorders / psychotic symptoms, headaches, confusion, depression, irritability,
insomnia, tachycardia, arrhythmia (irregular heart beat), atrial fibrillation, chest pain, erythema / flushing,
dehydration, agitation, dizziness; possible nephrotoxicity, cognitive, perceptual, and motor changes.
Due to the synergism between copper and aluminum, a higher intake or absorption of aluminum - ranging
from antiperspirants, tetra packs, all the way to municipal drinking water treated with aluminum sulphate and
polyaluminum chloride (used as coagulants) - will result in greater copper retention and lowered sulfur levels,
since both, aluminum and copper are sulfur antagonists.
High cellular copper levels, along with related sulfur deficiencies, can be considered to be one of the most
Higher estrogen levels from 'hormone replacement therapy,' birth control pills, and pregnancy, increase
intracellular copper and manganese levels, and they sometimes raise serum copper as well, which can
contribute to changes in sugar metabolism, oxygen metabolism (asthma), and a female's mental and
emotional well-being. Serum copper levels also generally increase during acute infections, whereas serum
iron levels decline during that time. The only genetic association to toxic copper overload is found in
Wilson's disease, which however is relatively rare.
Copper Toxicity or excessive copper levels  have been associated with physical and mental fatigue, sleep
disorders, depression and other mental problems, schizophrenia, learning disabilities, ADD / hyperactivity,
mood swings (sometimes violent, criminal or psychotic behavior) and general behavioral problems, memory
and concentration problems, some dementias, postpartum depression, increased risk of infections, vascular
degeneration, hemangiomas, headaches, weight gain, arthritis, spinal / muscle / joint aches and pains, and
several types of cancer.
Copper is a necessary component to support angiogenesis (formation of new blood vessels in tumors), so to
some extent, lowering copper reduces the risk to develop benign and malignant (cancerous) tumors. Nausea
and vomiting are not only common effects from copper toxicity, but they can also be experienced when Cu is
supplemented with acidic foods or beverages, on an empty stomach, or with higher amounts of ascorbic acid.
This does not apply to non-acidic forms of Vitamin C such as sodium ascorbate, or calcium ascorbate.
Low Copper intake can increase the risk of high serum cholesterol, coronary heart disease, irregular heart-
beat, decreased pigmentation of skin / vitiligo, premature graying hair, hernias, aneurysm (bulging of a blood
vessel wall), varicose veins, dermatitis, fatigue, anemia, anorexia, thyroid problems, allergies, poor healing,
lowered immunity, arthritis and fragile bones, neutropenia (low neutrophils), and mood & nervous disorders.
Although higher copper levels support angiogenesis with most tumors (particularly estrogen receptor-positive
types), colon cancer often develops in the presence of insufficient cellular copper, calcium, and potassium
levels. Menkes syndrome is a fatal disease usually affecting infants, and caused by faulty copper absorption.
Some people claim that Copper Bracelets help reduce the symptoms
of arthritis, whereby measurements do confirm an increase in intracellular
copper from wearing these bracelets and bands. Since copper is anti-
inflammatory, positive effects can be real and attributable to copper salts
being formed and absorbed as a result of copper reacting with fatty acids
in the skin. As long as copper is on the low side, this can be an effective
way to help increase copper levels, however in someone suffering from copper overload, the extra copper
absorbed from these bracelets can worsen existing medical symptoms resulting from copper levels that are
already too high, or they may over time create new medical problems in individuals whose copper levels were
Copper shares many attributes with calcium, whereby both can become bio-unavailable at high levels and
result in symptoms of deficiency! Some practitioners, being unaware of the underlying copper excess, and
lacking the resources to test intracellular levels of copper, get temporary results by having a patient supple-
ment more copper. Despite the initial improvement, this can have disastrous long-term effects on a patient's
physical and mental health.
The correct approach consists of making copper (or calcium) more bioavailable by supplementing the proper
co-factors, with the best choice being those whose levels are lowest ratio-wise to copper - and as mentioned
above - may include Vitamin C, chromium, sulfur (MSM), molybdenum, nickel, or (rarely) zinc. The avoidance
of foods high in copper is important as well.
This will take care of the medical conditions a practitioner was originally consulted for, and at the same time
prevents the potential development of new medical problems elsewhere related to excessive copper intake.
Chromium has to be considered first when trying to normalize copper, since it is its associated trace element.
Many aches and pains, arthritis, slow-healing fractures, sciatica and other back problems, various infections,
etc, can be relieved with chelated chromium (not GTF chromium), provided:
a) they conform to the left side-specific receptor requirements, b) calcium and magnesium are close to
normal, since they are also involved with various disorders of the musculoskeletal system, and c) potassium
levels are not below normal, since chromium is a potent potassium antagonist.
Following a close second is Sulfur, usually supplemented in the form of MSM, whose main action in addition
to helping restore cartilage formation is the lowering of copper! So again, it is the high copper levels which
created a need for sulfur to help reverse joint degeneration. Originally, glucosamine sulfate (another copper-
lowering sulfur compound) had been the non-drug treatment of choice for joint problems, however its blood
sugar raising potential has considerably reduced its popularity in individuals with blood sugar disturbances
(e.g. diabetes), so MSM has become the preferred choice instead.
Copper works synergistically with potassium and calcium, so when patients do exhibit low copper levels,
then calcium and potassium are frequently on the low side as well. Supplementing 3 mg of copper for one to
two weeks, or less, is all that is needed for an adult to normalize any copper deficiency, but then it should be
discontinued or reduced, otherwise copper may go too high.
One common effect of supplementing copper is weight gain - as much as 5% or more, which is also possible
when absorbing extra copper from non-dietary sources such as copper bracelets or copper IUDs. So unless
gaining weight is a welcome benefit, or a reliable test indicates insufficient levels, most people should avoid
mineral formulations containing either iron (which also causes weight gain), or more than 0.5 mg of copper.
If an adult does experience ongoing copper deficiency due to malabsorption disorders (e.g. celiac disease),
then appropriate amounts have to be regularly supplemented, or food sources with high copper content
(e.g. liver) would have to be consumed on a regular basis. Cocoa products are also a good choice. While
only moderately high in copper, they have superior copper bioavailability compared to other food sources.
It would also be worthwhile to check if excessive amounts of copper antagonists or co-factors are supple-
mented, which may be the reason for low copper levels.
2015 Dietary Reference Intake (DRI) - Recommended Dietary Allowance / Intake (RDA / RDI) for
Adults, Children, Pregnancy & Nursing - Adequate Intake (AI) - Tolerable Upper Intake Level (UL)
11-18 years males
19-50 years males
50 + years males
11-18 years females
19-50 years females
50 + years females
0.2 mcg AI
5.5 mcg AI
11 - 25 mcg AI
25 - 35 mcg AI
35 mcg AI
30 mcg AI
21 - 24 mcg AI
25 mcg AI
20 mcg AI
29 - 30 mcg AI
44 - 45 mcg AI
11-18 years males
19-50 years males
50 + years males
11-18 years females
19-50 years females
50 + years females
200 mcg AI
220 mcg AI
340 mcg - 700 mcg
700 mcg - 890 mcg
700 mcg - 890 mcg
Therapeutic Range: 200 mcg - 5,000 mcg +
Best time to take Chromium: Anytime - with food
(preferably), or without food, but hours apart from
taking copper, or high-potency potassium supplements.
UL: 1mg - 10mg
Therapeutic Range: 1mg - 10mg +
Best time to take Copper: Anytime - with non-
acidic foods / beverages to avoid nausea. Copper is
best taken by itself, without any other supplements.
General recommendations for nutritional supplementation: To avoid stomach problems and improve tolerance,
supplements should be taken earlier, or in the middle of a larger meal. When taken on an empty stomach or
after a meal, there is a greater risk of some tablets causing irritation, or eventually erosion of the esophageal
sphincter, resulting in Gastroesophageal Reflux Disease (GERD). It is also advisable not to lie down right after
taking pills. When taking a large daily amount of a single nutrient, it is better to split it up into smaller doses
to not interfere with the absorption of other nutrients in food, or nutrients supplemented at lower amounts.
Copyright © 2000-2015 Acu-Cell Nutrition - Copper & Chromium