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   Chromium & Copper
 
Both elements share left / right-sided cell receptors and are considered essential to human health.  Next to
calcium and magnesium, chromium and copper are important nutrients for their anti-inflammatory properties.
While neither one - with few exceptions - is generally found to be very deficient level-wise, chromium (Cr) is
on average always lower than copper (Cu), with virtually no exceptions.  Copper, on the other hand is elevated
in the majority of patients, which creates a chronic copper / chromium conflict ratio-wise in these individuals.

In fact, of all the patients I have tested since the mid 70's, nearly 90% exhibited a chemical profile that in
addition to their own unique chemistry contained an underlying pattern that reflected the impact of elevated
copper levels on various opposing nutrients, which include chromium, molybdenum, sulfur, nickel, Vitamin C,
and hesperidin, among others.

Although chromium appears to be normal on the following graph, it is very low in ratio to copper, its associ-
ated element, so when supplementing chromium, its level will generally not increase at first, but it will gradually
lower copper instead, and in the example below, potassium, since they are high in ratio to chromium.  Only
after copper and potassium have been reduced to normal levels, chromium may at that point start to go up.
However, since sufficient amounts of chromium are rarely used, in practice, copper and potassium just come
down closer to normal, and chromium levels stay the same.
Chromium / Copper & associated mineral interactions
Magnesium frequently goes up following long-term chromium supplementation because of its synergism with
chromium, and as a result of potassium (which is a magnesium antagonist) going down, and thus not exerting
an inhibiting effect on magnesium any longer.

There are other copper antagonists such as zinc, however while zinc is generally documented as such in the
nutritional literature, it is not only the weakest of all copper antagonists, but its action on copper takes place
only on an intestinal level, so once copper goes into storage, zinc will have no effect on lowering copper any
longer.  The only time zinc could become a threat to copper is in situations where either copper levels are
already on the low side and high amounts of zinc are consumed, or when potassium and calcium - being
"synergistic allies" to copper - are below normal.

Many people exhibit high levels of zinc and copper, in which case a common denominator such as Vitamin C
has to be supplemented in larger amounts to help lower both, while foods such as shellfish, nuts, wheat germ,
(containing high levels of copper and zinc), should be avoided.  One major reason why some people require
a much higher intake of Vitamin C compared to others is that they exhibit very high levels of copper, which in
these people happens to interfere with nickel and Vitamin C metabolism (see "Vitamin C Supplementation").
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Copper is present in all tissues.  The average adult body contains about 80 to 120mg of copper, of which
most of it is stored in the liver.  It is an important catalyst in the formation of the oxygen-carrying molecule
hemoglobin.  Copper is transferred by albumin across the gut wall and carried to the liver where it is formed
into ceruloplasmin, a copper transport protein.  Sufficient ceruloplasmin levels affect a decrease in the
absorption of copper to minimize copper toxicity.

Copper is an essential component of several physiologically important enzymes, including

   • cytochrome oxidase, which is necessary for energy metabolism, cellular respiration, and myelin
      formation,

   • superoxide dismutase (SOD), which helps slow down age-related deterioration of the body, protects
      from developing chemical sensitivities (along with polyphenol oxidase), and it is important for normal
      humoral immune response,
   • histaminase, which breaks down histamine, to control allergies and inflammation,
   • lysil oxidase, which is necessary for the formation of the cross-links of collagen and elastin,
   • tyrosinase, which is associated with normal pigmentation and keratinization of hair,
   • dopamine-beta-hydroxylase, with which copper serves as a cofactor in the synthesis of
     norepinephrine, an important neurotransmitter and adrenal hormone that affects fatigue, mood and
     depression.

Chronically elevated copper levels in most patients may result from one-sided diets that lack co-factors or
copper antagonists, or from the fact that many copper-rich foods are somewhat addictive, such as cocoa /
chocolate products, colas, coffee, or tea.  Other sources include seafood / shellfish, seeds and nuts, liver,
soy products, foods or beverages that are cooked or stored in copper containers (beer), tap water (copper
plumbing), and copper IUDs.

Due to the synergism between copper and aluminum, a higher intake or absorption of aluminum - ranging
from anti-perspirants, tetra packs, all the way to municipal drinking water treated with aluminum sulphate and
polyaluminum chloride (used as coagulants) - will result in greater copper retention and lowered sulfur levels,
since both, aluminum and copper are sulfur antagonists.
High cellular copper levels, along with related sulfur deficiencies, can be considered to be one of the most
prominent causes of many physical and mental health problems, including ADD and Alzheimer's Disease.

Higher estrogen levels from Hormone Replacement Therapy (HRT), pregnancy, and taking birth control pills
increase intracellular copper and manganese levels, and they sometimes raise serum copper as well, which
can contribute to changes in sugar metabolism, oxygen metabolism (asthma), and a female's mental and
emotional well-being. Serum copper levels also generally increase during acute infections, whereas serum
iron levels decline during that time.  The only genetic association to toxic copper overload is found in
Wilson's disease, which however is relatively rare.

Copper Toxicity or excessive copper levels have been associated with physical and mental fatigue, sleep
disorders, depression and other mental problems, schizophrenia, learning disabilities, hyperactivity / ADD,
mood swings (sometimes violent, criminal or psychotic behavior) and general behavioral problems, memory
and concentration problems, some dementias, postpartum depression, increased risk of infections, vascular
degeneration, hemangiomas, headaches, arthritis, spinal / muscle / joint aches and pains, and several types
of cancer.
Copper is a necessary component to support angiogenesis (formation of new blood vessels in tumors), so to
some extent, lowering copper reduces the risk to develop benign and malignant (cancerous) tumors.  Nausea
and vomiting are not only common effects from copper toxicity, but they can also be experienced when Cu is
supplemented on an empty stomach, with acidic foods or beverages, or with taking higher amounts of Vit C.

Low Copper intake can increase the risk of high blood cholesterol, coronary heart disease, irregular heart-
beat, decreased pigmentation of skin / vitiligo, premature graying hair, hernias, aneurysm (bulging of a blood
vessel wall), varicose veins, dermatitis, fatigue, anemia, anorexia, thyroid problems, allergies, poor healing,
lowered immunity, arthritis and fragile bones, neutropenia (low neutrophils), mood and nervous disorders.
Menke's disease is a rare problem of copper malabsorption in male infants.

Some people claim that Copper Bracelets help reduce the symptoms of arthritis, whereby measurements
do confirm an increase in intracellular copper from wearing these bracelets and bands.  Since copper is anti-
inflammatory, positive effects can be real and attributable to copper salts being formed and absorbed as a
result of copper reacting with fatty acids in the skin.  As long as copper is on the low side, this can be an
effective way to help increase copper levels, however in someone suffering from copper overload, the extra
copper absorbed from these bracelets can worsen medical symptoms resulting from copper levels that are
already too high, or they may over time create new medical problems in individuals whose copper levels were
previously normal.

Copper shares many attributes with calcium, whereby both can become bio-unavailable at high levels and
result in symptoms of deficiency! (see also Acu-Cell "Calcium & Magnesium").  Some practitioners, being
unaware of the underlying copper excess, and lacking the resources to test intracellular levels of copper, get
temporary results by having a patient supplement more copper.  Despite the initial improvement, this can
have disastrous long-term effects on a patient's physical and mental health.
The correct approach consists of making copper (or calcium) more bioavailable by supplementing the proper
co-factors, with the best choice being those whose levels are lowest ratio-wise to copper - and as mentioned
above - may include Vitamin C, chromium, sulfur (MSM), molybdenum, nickel, or (rarely) zinc.  Avoidance of
foods high in copper is of utmost importance as well.
This will take care of the medical conditions a practitioner was originally consulted for, and at the same time
prevents the potential development of new medical problems elsewhere related to excessive copper intake.

Chromium is the "Gold Standard" to help normalize elevated copper, since it is its associated trace element.
Many aches and pains, arthritis, slow-healing fractures, sciatica and other back problems, various infections,
etc, can be relieved with chelated chromium (not GTF), provided they conform to the side-specific (receptor)
requirements, provided that calcium and magnesium are close to normal, since they are also involved with
various disorders of the musculoskeletal system, and provided that potassium levels are not below normal,
since chromium is a potent potassium antagonist.

Following a close second is sulfur, usually supplemented in the form of MSM, whose main action in addition
to helping restore cartilage formation is the lowering of copper!  So again, it is the high copper levels which
created a need for sulfur to help reverse joint degeneration.  Originally, glucosamine sulfate (another copper-
lowering sulfur compound) had been the non-drug treatment of choice for joint problems, however its insulin-
depressing potential has considerably reduced its popularity in individuals with hyperglycemic (high blood
sugar) tendencies, so MSM has become the preferred choice instead. (see also Acu-Cell "Sulfur").

Copper works synergistically with potassium and calcium, so when patients do exhibit low copper levels,
then calcium and potassium are frequently on the low side as well.  Taking a 3 mg copper pill for two to three
weeks, or less, is all that is needed for an adult to normalize any copper deficiency, and then it should usually
be discontinued, otherwise copper may go too high - being another reason why most people should avoid
multi-mineral formulations containing more than 1 mg of copper.
Chromium occurs in any oxidation state from -2 to +6.  Trivalent chromium (Cr+3) is the biologically active
form, while hexavalent chromium (Cr+6) is potentially toxic to humans.  GTF (Glucose Tolerance Factor)
chromium is essential in helping regulate carbohydrate metabolism by improving the uptake of glucose into
the cells so it can be metabolized to produce energy (ATP).  It consists of chromium in the trivalent state -
nicotinic acid, and the three amino acids glycine, glutamic acid and cysteine.

Chromium is able to improve cholesterol and triglyceride status, however while small amounts are necessary
for normal carbohydrate metabolism and to help with blood sugar management in diabetics, supplementing
higher amounts of chromium will not reverse Type II diabetes, as some sources claim.

On a similar note, Chromium Picolinate (chromium + picolinic acid) does not increase lean muscle tissue
and decrease body fat, as advertised by other sources.  In fact, in contrast to the control groups, some of the
participants in the chromium picolinate group actually gained weight (one of my patients took part in that
research), and one published medical report stresses the implications of analogues of picolinic acid being
able to cause significant behavioral changes in those with an increased susceptibility for mood disorders.
Chromium picolinate is clearly the least desirable form to be used for supplementation (see below for more
adverse effects).

Tissue concentrations of chromium vary considerably in people from different parts of the world, with amounts
in people living in Asia for example being up to five times higher compared to those in people living in the US.
These higher chromium levels may be one reason for a lower incidence of bone loss, or sugar metabolism
disorders in these regions or countries.  In addition, excessive sugar intake - prevalent in Western societies -
increases chromium loss and accelerates already declining levels due to increasing age, which worsens
medical conditions associated with lowered chromium levels.
There are also lower soil levels of chromium in North America, and the refining process of food (sugar cane,
whole grains) reduces sources of chromium as well.  Exercise and trauma also contribute to chromium loss,
and it is interesting to note that in laboratory animals, extra chromium supplementation resulted in a life span
increase of up to 33%.

Uptake of various forms of chromium, including GTF chromium is in a low 1 - 3% range, with the absorption of
Chelated Chromium being usually closer to 25%, so chelated chromium is the preferable choice for specific
medical applications.  For instance, when chromium is used for inflammatory conditions such as an acute
bladder infection (cystitis), taking 20,000 mcg of GTF chromium has little or no effect at all on improving the
symptoms, while 2 - 3,000 mcg / day of chelated chromium will rectify most cases of cystitis, or it can be used
to resolve chronic bladder infections by having patients take a lower, preventative maintenance amount.

Osteoporosis of trabecular bone (spine, or end-part of bone) is frequently caused by chromium being very
low in ratio to either copper, potassium, selenium, and/or rarely, vanadium.  Chromium is required for proper
parathyroid functions, so any of these Cr antagonists can become responsible for bone loss if supplemented
needlessly, or if their levels remain too high too long for any other dietary or genetic reason.  However, one
other major factor that is responsible for bone loss as a result of its chromium-lowering effect - particularly in
Western Societies - and which is being totally overlooked is Sugar, and all other Simple Carbohydrate
sources! (see also Acu-Cell "Osteoporosis" and "Sugar & Glycemic Index").  ¤
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Dietary Reference Intake (DRI) is the latest term replacing daily dietary reference values such as
Adequate Intake (AI), Tolerable Upper Intake Level (UL), Estimated Average Requirements (EAR),
Nutrient Reference Value (NRV),  and Recommended Dietary Allowance / Intake (RDA / RDI).

Chromium:Copper:

DRI (RDA):DRI (RDA):
0-6 months10mcg - 40mcg0-6 months0.5mg - 0.7mg
6-12 months20mcg - 60mcg6-12 months0.7mg - 1mg
1-10 years30mcg -150mcg1-10 years1mg -2.5mg
11-18 years100mcg - 200mcg11-18 years2mg - 3mg
18 years +200mcg+18 years +3mg
pregnant / lactating+ 50mcg

Therapeutic Range:200mcg - 3,000mcg+Therapeutic Range:1mg - 5mg
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Cellular / Intracellular Attributes and Interactions:

Chromium Synergists:Copper Synergists:
Magnesium, zinc, Vitamin B15,Calcium, potassium, Vitamin E,

Chromium Antagonists / Inhibitors:Copper Antagonists / Inhibitors:
Selenium, vanadium, potassium, cobalt, copper,Sulfur, molybdenum, zinc, nickel, Vit B6, Vit C,
iodine, Vitamin B12, rutin, sugar, alcohol, fat,chromium, tin, hesperidin, insoluble fiber,

Low Levels / Deficiency - Symptoms and/or Risk Factors:

Chromium:Copper:
Reduced glucose tolerance / impaired glucoseAnemia, increased susceptibility for infections,
metabolism, weakened immune system, increasedweakened immune system, increased risk for
susceptibility for infections (e.g. bladder, left tonsil),cancer, vascular degeneration, inflammatory
trabecular bone loss, inflammatory joint disease,joint disease, trabecular bone loss, premature
elevated total cholesterol, birth defects, reducedgraying of hair / loss of hair color, leukopenia,
life expectancy, nerve degeneration,hormonal disorders, miscarriage, stroke,
 insomnia, irregulat heart beat (arrhythmia),
 nerve degeneration, cardiomyopathy (in rats),

High levels / Overdose / Toxicity / Negative Side Effects - Symptoms and/or Risk Factors:

Chromium:Copper:
Spinal / joint degeneration, depressed immuneWilson's disease, anemia, nausea, vomiting,
system, lymphatic swelling,abdominal pain, moodiness, depression,
 ADD / ADHD, confusion, violent behavior,
Please Note:  Additional (rare) overdose / toxicityarthritis, joint / spinal degeneration, higher risk
symptoms are the result of a high chromium intakefor some cancers, increased susceptibility for
causing deficiencies of other elements or nutrients.infections, heart disease and stroke, vascular
These are found in their respective "Deficiency"degeneration (varicose veins, aneurysms,
category and include potassium, copper, vanadium,bruising, hemorrhoids), hemangiomas,
selenium, cobalt, iodine, Vitamin B12, and rutin.

Chromium Picolinate:
Weight gain, behavioral disorders / psychotic symptoms, headaches, confusion, depression, irritability,
insomnia, tachycardia, arrhythmia (irregular heart beat), atrial fibrillation, chest pain, erythema / flushing,
dehydration, agitation, dizziness;  possible nephrotoxicity, cognitive, perceptual, and motor changes.
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Chromium Sources:Copper Sources:
Brewer's yeast, beef, liver, chicken, dairy products,Wheat germ, oats, fish / shellfish, mushrooms,
eggs, potatoes, whole-grain products, fish / seafood,soybeans, seeds, coffee, tea, cocoa products,
green peppers, bananas, beer, drinking water,liver, nuts, drinking water (copper plumbing). ¤

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General recommendations for nutritional supplementation:  To avoid stomach problems and promote better
tolerance, supplements should always be taken earlier, or in the middle of a larger meal.  When taken on an
empty stomach or after a meal, there is a greater risk of some tablets causing irritation, or eventually erosion
of the esophageal sphincter, resulting in Gastroesophageal Reflux Disease (GERD).  It is also advisable not
to lie down immediately after taking any pills.  When taking a very large daily amount of a single nutrient, it is
better to split it up into smaller doses to not interfere with the absorption of other nutrients in food, or nutrients
supplemented at lower amounts.

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Copyright © 2000-2010  Ronald Roth                      Acu-Cell Nutrition: Copper & Chromium
  
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