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    Fluoride & Chloride
 
Both elements share left / right-sided cell receptors and are considered essential to human health - although
there is still controversy among some authorities in regard to the essentiality of fluoride and its value in human
nutrition.

Fluorine (F) is an essential hardening component of bone and it is present at about 4% as calcium fluoride,
whereby too little fluoride has a weakening effect on bone, while too much fluoride causes brittleness of bone
and thus increases fracture rates.  Fluoride is absorbed through the gastrointestinal tract, however just as with
chlorine, another route of absorption may be through inhalation.
Nearly all the fluoride of soluble compounds such as sodium fluoride may be absorbed when ingested with
water, although the hardness of water has some effect on fluoride uptake -- e.g. a high calcium or magnesium
content, or the presence of high levels of aluminum will reduce the bioavailability of fluoride.

Approximately half the absorbed fluoride is excreted in the urine, while most of the retained fluoride becomes
part of bone and other calcified tissues.  However, a reduced fluoride intake over a long period of time will
result in mobilization of bound fluoride from storage sites, and subsequently lower concentrations in bone.

Much of the controversy surrounding fluoride comes from its legislated addition to city water in many munici-
palities in an effort to reduce dental caries in children.  There are clearly two very divided camps arguing for
and against the benefits of fluoridation of municipal drinking water, with one side claiming a 30% -70%
reduction in dental caries and reduced fractures with osteoporosis, while the other side refers to research
studies showing an increase in hip fractures instead and proof that dental caries declined as much in non-
fluoridated municipalities as in the fluoridated ones.

In addition, they argue that in certain regions, there is an excess of fluoride, which has resulted in mottling
of teeth in children, and that numerous studies have implicated high fluoride intake as being responsible for
lowered IQ and learning ability.  There are also fluoridated and non-fluoridated city to city comparisons, where
statistics show thousands of cancer deaths attributable to mandatory fluoridation of public water systems.

Assessments of these studies prepared for the Canadian Government by the Faculty of Dentistry at the
University of Toronto had this to say regarding any correlation of high fluoride to lowered IQ and cancer:

      • Re IQ:  "Recent studies emanating from China have claimed that children exposed to high levels of
      fluoride have lower IQ's than children exposed to low levels.  The two studies claiming such an effect
      are deeply flawed and provide no credible evidence that fluoride obtained from water or industrial
      pollution affects the intellectual development of children."

      • Re Cancer:  "The few studies published during the review period do not challenge earlier research
      showing that there is no reason to believe that exposure to fluoridated water increases the risk of cancer
      in bones or other body tissues.  While an ecological study did suggest an association with uterine cancer,
      the limitations of this kind of study in terms of linking exposures and outcomes in individuals, mean that it
      does not contradict the evidence derived from more systematic and scientifically credible case-control
      studies."

A 1990 fluoride study confirmed an increase in cancers of the oral mucus membranes (squamous cell carci-
noma) in rats; a rare form of osteosarcoma appeared at double the rate in males as females; and there was
an increase in thyroid follicular cell tumors, and liver cancer.
However, a 1991 review by the U.S.Public Health Service concluded that there is no evidence that fluoride
causes cancer in humans.  The incidence of bone cancer in males below the age of 20 has risen since 1973,
but the panel concluded that this is not related to fluoridation.

The Public Health Service review recommended further studies to determine the relationship between
fluoride intake and bone fractures.  The National Research Council also concluded that current levels of
fluoride in drinking water do not increase the risk of kidney disease, birth defects or intestinal problems.
A number of European countries have now abandoned the fluoridation of public water systems, while the
controversy on this continent continues...
Chlorine (Cl) exists primarily as the chloride anion that joins with cations such as sodium to make salt (table
salt / sodium chloride), and with hydrogen to make stomach acid (hydrochloric acid), but while chloride is a
constituent of stomach acid, high or low chloride levels are not an actual indicator of stomach acid levels.  It is
necessary for protein digestion (pepsin), Vitamin B12 absorption (intrinsic factor), and absorption of metallic
minerals.
When stomach acid is neutralized, chloride is reabsorbed by the intestine and recycled.  Being one of the
electrolytes, chloride works closely with sodium and potassium and is part of the controlled regulation of acid-
alkaline balance. Heavy perspiration can cause a considerable amount of sodium chloride and potassium to
be lost.

Chlorine is used in treating drinking water, swimming pools, hot tubs...etc, to kill bacteria and other micro-
organisms.  It is also a building block for PVC (polyvinyl chloride) and numerous other chemicals such as
antifreeze, pesticides, refrigerants, and anti-knock compounds.  As sodium hypochlorite, or bleach, it is
widely used as a disinfectant and in bleaching.  Mixing bleach with other cleaning agents, such as ammonia,
can expose children or the elderly to dangerous gases.

Some studies claim that more than half of our harmful exposure to chlorine is due to the inhalation of steam
and skin absorption while showering, with the steam containing up to 50x the chemical levels compared to
drinking water, and with chlorine and most other contaminants vaporizing faster and at a lower temperature
than water.  In addition, inhaled chlorine gas (chloroform) goes directly into our blood stream, subsequently
bypassing the kidneys and digestive system where it would be partly filtered out.

There is also much concern about the levels of residual chlorine in drinking water, because excess chlorine
is thought to combine with certain organic water pollutants to form toxic chemicals and carcinogens such as
trihalomethanes.
Several epidemiological studies, including research from the National Cancer Institute and 10 other organiza-
tions linked the chlorination of drinking water to increasing an individual's risk of developing bladder cancer,
with some of the studies also claiming a higher incidence of Hodgkin's disease, colorectal, esophageal and
breast cancer.
According to these claims, women with breast cancer have 50 - 60% higher levels of organochlorines
(chlorination byproducts) in their breast tissue compared to women without breast cancer.  Chlorination has
also been associated with declining sperm counts, male infertility, and circulatory disturbances based on
some animal studies.

 *          *          *

Fluoride & Chloride interact with some Carotenoids (beta-carotene), whereby sufficient intake positively
affects the absorption of both elements.  As a result, and considering the widespread use of fluoridated
toothpastes, supplementation of fluoride for children in the form of drops or chewable tablets (such as Fluor-
A-Day) to reduce cavities is not necessary or advisable.  Low levels of fluoride and/or chloride tend to
adversely affect bowel functions and sinuses, resulting in greater incidences of inflammation, so adequate
carotenoid intake (including lutein, for macular degeneration) is important for preventive or corrective
purposes.

High levels of fluoride and/or chloride can trigger ringing / noises in the ear (tinnitus), and may eventually lead
to progressive hearing loss.  No extra beta-carotene should be supplemented in those instances, but only
preformed Vitamin A, if deficient.

When Potassium Supplementation is indicated, the use of non-chloride types such as Potassium Citrate
may be preferable for better tolerance, or where specific medical situations, such as osteoporosis, polycystic
kidney disease, or kidney stones may be aggravated by the use of Potassium Chloride.  On the other hand,
individuals on a salt-restricted diet and a tendency for low stomach acid may do better with chloride-types of
potassium, or chloride-types of other minerals they supplement.  ¤
___________________________________________________________________________________
===================================================================================

Dietary Reference Intake (DRI) is the latest term replacing daily dietary reference values such as
Adequate Intake (AI),  Tolerable Upper Intake Level (UL),  Estimated Average Requirements (EAR),
Nutrient Reference Value (NRV),  and Recommended Dietary Allowance / Intake  (RDA / RDI).

Fluorine / Fluoride:Chlorine / Chloride:

DRI (RDA):DRI (RDA):
0-6 months0.1mg - 0.5mg0-6 months0.3g - 0.7g
6-12 months0.2mg - 0.7mg6-12 months0.4g - 1.2g
1-10 years0.7mg - 2.5mg1-10 years0.5g - 2.5g
11-18 years1.5mg - 3.0mg11-18 years1.5g - 4.5g
18 years +2.0mg- 3.5mg18 years +1.8g - 5.1g

Therapeutic Range:2mg - 50mg+Therapeutic Range:2g - 20g+
___________________________________________________________________________________

Cellular / Intracellular Attributes and Interactions:

Fluoride Synergists:Chloride Synergists:
Carotenoids, Vitamin D, molybdenum,Carotenoids, vanadium, [fluoride],
stomach acid, black tea, [chloride],

Fluoride Antagonists / Inhibitors:Chloride Antagonists / Inhibitors:
Iodine, calcium, magnesium, aluminum, [chloride]Tin, calcium, magnesium, bromine, [fluoride],
protein, milk,

Low Levels / Deficiency - Symptoms and/or Risk Factors:

Fluoride:Chloride:
Weakened bone, dental caries,Metabolic alkalosis, apathy, dehydration,
 In children: slowed growth, delayed speech,

High levels / Overdose / Toxicity / Negative Side Effects - Symptoms and/or Risk Factors:

Fluoride:Chloride:
Increased bone fractures, fluorosis (discoloration /Edema / fluid retention, hypertension / high
mottling, pitting of teeth), osteosclerosis, tinnitus,blood pressure, greater risk of some cancers,
hearing loss, delayed brain development, tremors,Chlorine inhalation: Coughing, choking, chest
bone / arthritic pains, greater risk of some cancers,pains, pulmonary edema, asthma, headache,
skin rash, nausea, vomiting, gastrointestinal irritation,blue discoloration of skin, nausea, vomiting,
stomach ulcers, convulsions, death.
___________________________________________________________________________________

Fluoride Sources:Chloride Sources:
Seafood, gelatin, black tea, tap water (some cities),Salt, sea salt, vegetables, celery, tomatoes,
some mineral waters, most toothpastes, pesticides,olives, lettuce, salt substitutes (KCl).
chewing tobacco, tamarind, some wines. ¤

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===================================================================================

General recommendations for nutritional supplementation:  To avoid stomach problems and promote better
tolerance, supplements should always be taken earlier, or in the middle of a larger meal.  When taken on an
empty stomach or after a meal, there is a greater risk of some tablets causing irritation, or eventually erosion
of the esophageal sphincter, resulting in Gastroesophageal Reflux Disease (GERD).  It is also advisable not
to lie down immediately after taking any pills.  When taking a very large daily amount of a single nutrient, it is
better to split it up into smaller doses to not interfere with the absorption of other nutrients in food, or nutrients
supplemented at lower amounts.

___________________________________________________________________________________
Copyright © 2000-2010  Ronald Roth             Acu-Cell Nutrition: Fluoride & Chloride
  
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